About Syndesi Therapeutics Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate. We make long term investments in early stage companies in the US and Europe. Syndesi is investigating the potential of these molecules to improve cognition in diseases such as Alzheimer's Disease and other dementias, as well as other conditions such as major depression and cognitive impairment associated with schizophrenia. Syndesi Therapeutics' lead pipeline candidate is SDI-118. document.getElementById('cloak45869').innerHTML += '' + addy45869+'<\/a>'; Novo Seeds is the early-stage investment arm of Novo Holdings (www.novoholdings.dk). About Syndesi Therapeutics. Our Pipeline Job Postings. About Syndesi Therapeutics Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. AbbVie has acquired Belgium-based company Syndesi Therapeutics in a deal worth up to $1bn, expanding its neuroscience portfolio. The Company's approach is aimed at treating Alzheimer's Disease and other disorders with cognitive impairment. Therefore we make use of cookies. All rights reserved. ABOUT HD; ABOUT ALS; NEWS. Obsidian Therapeutics is using its proprietary cytoDRiVE platform to harness the power of proteins to engineer precision medicines. We are deploying our platform to build a pipeline of first-in-class small molecules to address high priority cancer targets that have evaded conventional discovery approaches. Syndesi Therapeutics (www.syndesitherapeutics.com) has been established at the Centre dEntreprises et dInnovation (CEI) in Louvain-la-Neuve and will have a presence at the JLINX incubator facilities to access expertise at the Janssen campus in Beerse, Belgium. Their latest funding was raised on Sep 28, 2020 from a Series A round. Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). UCB identified novel modulators of SV2A that show pro-cognitive properties in preclinical models. Products or potential products which are the subject of partnerships, joint ventures or licensing collaborations may be subject to differences between the partners. I am thrilled to be working with the company which is supported by scientists at UCB and able to leverage Janssen neuroscience expertise via a presence at the JLINX incubator, all in an effort to develop products that could one day make a meaningful difference for patients suffering from cognitive impairment.. 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The company has also benefited from support from the Walloon Region. AbbVie has acquired Belgium-based company Syndesi Therapeutics in a deal worth up to $1bn, expanding its neuroscience portfolio. You need JavaScript enabled to view it. Milestone payments could bring shareholders of the biotech up to $870. The company's drugs can modulate the synaptic vesicle protein to handle the transmission between neurons in the brain to effectively treat Alzheimer's and other disorders with cognitive impairment, enabling healthcare providers to treat these diseases with the right therapy at their disposal. Syndesi was created through a partnership between UCB Biopharma SRL and a syndicate of Belgian and international investors to further develop novel SV2A modulators that had been originally discovered by UCB. NORTH CHICAGO, IL, USA I March 1, 2022 I AbbVie (NYSE: ABBV) today announced it has completed the acquisition of Syndesi Therapeutics SA, which will help to expand AbbVie's neuroscience portfolio. This page shows the latest Syndesi Therapeutics news and features for those working in and with pharma, biotech and healthcare. Clinical studies at UCB: How are medicines made and tested? Syndesi Therapeutics is funded by 9 investors. www.jjdc.com. Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). Regulating synaptic transmission represents a promising approach to treating Alzheimers Disease and other disorders with cognitive impairment. WHO WE ARE . Unlike, UCB is the world leader in SV2A research, having discovered and developed two major anti-epileptic drugs treating patients around the world. Stay up-to-date on the latest news and information from UCB, 2007 - 2022UCB S.A., Belgium. Regulating synaptic transmission represents a promising approach to treating Alzheimer's Disease and other disorders with cognitive impairment. UCB, Brussels, Belgium (www.ucb.com) is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases in immunology and neurology. According to the deal, shareholders of Syndesi will receive an upfront payment of $130m from AbbVie. Syndesi Therapeutics's Chief Executive Officer is Jonathan Savidge. AbbVie Acquires Syndesi Therapeutics, Strengthening Neuroscience Portfolio. Goodwin Procter LLP acted as lead legal counsel, along with Deloitte Legal, Belgium, and Lazard acted as the exclusive financial adviser to Syndesi. Also, UCB or others could discover safety, side effects or manufacturing problems with its products after they are marketed. The product, which came to AbbVie in the 2020 Allergan acquisition, is approved for a range of therapeutic indications that include treating muscle spasticity from a stroke or other injury, as well as preventing migraine headaches. X. AbbVie adds to neuroscience pipeline with $1bn Syndesi buy. With more than 7500 people in approximately 40 countries, the company generated revenue of 4.2 billion in 2016. Anthos Therapeutics is a clinical-stage biopharmaceutical company focused on the development and commercialization of genetically and pharmacologically validated innovative therapies to advance care for people living with cardiovascular and metabolic (CVM) diseases. MT-2000 is a class of agents that are designed to precisely convert pro-inflammatory M1 Macrophages to anti-inflammatory M2 macrophages. Now, as part of AbbVie, the program is well positioned to move into later stages of clinical development.". Novo Holdings is a private limited liability company wholly owned by the Novo Nordisk Foundation. Learn More. We use cookies on our website to optimize your experience, analyze site usage, and to assist with our marketing activities. In the life science sector, SRIW is investor in more than 30 companies such as I.B.A., Celyad, or Ogeda of which it recently exited. The funds (VIVES I - 15 million and VIVES II - 43 million) are managed by SOPARTEC, UCLs technology transfer company, member of the Louvain Technology Transfer Office. As hospitals face consolidation and CIOs are asked to increase staff productivity, tech companies that can support automation with solutions that are easy to onboard are getting heightened interest. Type North Chicago, Illinois-based AbbVie announced Tuesday that it paid $130 million up front to acquire Syndesi Therapeutics. Revolutionary intracellular screening platform creates new opportunities to discover first-in-class therapeutics to address challenging disease targets. Pipeline Prospector delivers free access to a database of drugs under clinical trials which made headlines done by Syndesi Therapeutics The fund invests throughout Europe in start-up and early-stage companies with high growth potential focusing on technologies that provide transformational improvements in the biopharmaceutical, pharmaceutical, diagnostics and agricultural sectors. Syndesi Therapeutics is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. On Mar 2, 2022 AbbVie announced it has completed the acquisition of Syndesi Therapeutics SA, which will help to expand AbbVie's neuroscience portfolio. Read More Our Science There is a major unmet need for new therapies that can help improve cognitive function in patients suffering from difficult-to-treat neurologic diseases, Hudson said in a prepared statement. Connecting Health Systems and Life Science Researchers To Maximize the Potential of Real-world Evidence. More. Company Presentation . The mechanism is now being studied to potentially treat cognitive impairment and other symptoms linked to various neurodegenerative and neuropsychiatric diseases such as major depressive disorder and Alzheimers disease. Aristea Therapeutics Announces Dosing of First Patient in Phase 2a Trial of RIST4721 in Hidradenitis Suppurativa; August 26 2022 | News No Myth: CEO of ADC upstart calls it quits; Bristol Myers vet Jon Wigginton scales new heights at Bright Peak; August 24 2022 | News Appointments and advancements for Aug. 24, 2022; August 24 2022 | Press Releases flanders.bio wants to improve your user experience on this website. On March 1, 2022 AbbVie (NYSE: ABBV) reported it has completed the acquisition of Syndesi Therapeutics SA, which will help to expand AbbVie's neuroscience portfolio (Press release, AbbVie, MAR 1, 2022, View Source [SID1234609248]). PATIENTS & FAMILIES. Join our mailing list. Therapeutic botox accounted for $2.45 billion in 2021 sales, making it the companys top neuro product. AbbVie R&D senior vice-president and chief scientific officer Tom Hudson said: There is a major unmet need for new therapies that can help improve cognitive function in patients suffering from difficult-to-treat neurologic diseases. 3D Printing in Healthcare Market Size, Share, Trends Analysis Report By Region, Component (Hardware, Materials, Digital Marketing Trends in Colorectal Cancer. "I am delighted with the closing of this deal. AbbVie will pay Syndesi's shareholders a $130 million upfront payment with the potential for Syndesi's shareholders to receive additional contingent payments of up to $870 million based on the achievement of certain predetermined milestones. var path = 'hr' + 'ef' + '='; Tick the boxes of the newsletters you would like to receive. the acquisition further reinforces abbvie's neurology pipeline, as four years ago, syndesi therapeutics gained the rights to ucb's synaptic vesicle protein 2a (sv2a) programme, which aims to achieve synaptic efficiency, targeting the communication between neurons in the brain, which - most notably in alzheimer's - typically deteriorates as LEARN MORE V-Bio Ventures (www.v-bio.ventures) is an independent venture capital firm specialized in building and financing young, innovative life science companies. Syndesi will build on a rich legacy of work by UCB to further develop these novel SV2A modulators to investigate their potential to improve cognition in diseases such as Alzheimers Disease, other dementias and cognitive impairment associated with schizophrenia. Cognitive impairment observed in various neuropsychiatric and neurodegenerative ailments is claimed to be triggered by synaptic dysfunction. About Syndesi Therapeutics . The mechanism is currently being evaluated . Milestone payments could bring shareholders of the biotech up to $870 million more. Syndesi Therapeutics was established to develop a series of novel, pro-cognitive small molecule SV2A modulators licensed from UCB. Prilenia Therapeutics. We are excited to see Syndesi develop our novel pro-cognitive SV2A modulators to create value for patients with cognitive impairment, said Dhavalkumar Patel, UCBs Chief Scientific Officer and Executive Vice President. For more information about AbbVie, please visit us atwww.abbvie.com. . There is no guarantee that new product candidates in the pipeline will progress to product approval or that new indications for existing products will be developed and approved. A weekly roundup of the latest news and analysis, sent every Friday. More from news Approximately 1 fully matching, plus 0 partially . AbbVies portfolio and pipeline is thin on brain drugs, particularly in the area of neurodegeneration. MT . "We have been impressed with the vision of AbbVie's neuroscience R&D team, who share our view on the therapeutic potential of SDI-118 in a range of neurologic diseases," said Jonathan Savidge, chief executive officer, Syndesi Therapeutics. PIPELINE. Read more Press releases With AbbVies acquisition of Syndesi, we aim to advance the research of a novel, first-in-class asset for the potential treatment of cognitive impairment associated with neuropsychiatric and neurodegenerative disorders.. Syndesi Therapeutics has raised a total of 26.2M in funding over 3 rounds. SRIW Socit Rgionale d'Investissement de Wallonie (www.sriw.be) provides equity and/or debt to companies that generate added value and employment in Wallonia. Synaptic dysfunction is believed to underlie the cognitive impairment seen in multiple neuropsychiatric and neurodegenerative disorders. Clinical trial records show the drug is currently in two Phase 1b tests, one enrolling elderly patients with cognitive decline and the other testing the drug candidate in adults in remission from depression. This acquisition gives AbbVie access to Syndesi's portfolio of novel modulators of the synaptic vesicle protein 2A (SV2A), including its lead molecule SDI-118. 2022 Breaking Media, Inc. All rights reserved. addy45869 = addy45869 + 'lamerie' + '.' + 'com'; and we will provide you with regular updates. UCB is providing this information as of the date of this press release and expressly disclaims any duty to update any information contained in this press release, either to confirm the actual results or to report a change in its expectations. Regulating the synaptic transmission is a promising approach to treat Alzheimer's disease and other disorders with cognitive impairment. The company is rooted in the groundbreaking research of the VIB laboratory of Ludo Van Den Bosch and in the collaboration between the VIB labs of Joris de Wit and Bart De Strooper. +972 77 555 8482 +31 35 808 0509 Presently in Phase Ib clinical trials, SDI-118 is being analysed for its potential ability to boost synaptic efficiency by acting on nerve terminals. Contact Information Website www.syndesitherapeutics.com Follow @abbvie on Twitter, Facebook, Instagram, YouTubeand LinkedIn. Alkermes Weighs Splitting Off Cancer Biz as Separate, Publicly Traded Company, The 2 Things That Made My Transition to Voice Tech Easier: A Friendly Pricing Model and Easy Implementation, Patient Files Class-action Suit Against Advocate Aurora Health Following Data Breach, Why are Healthcare Costs So High? Get the latest industry news first when you subscribe to our newsletter. All rights reservedLast updated on:April, 07, 2022, Syndesi Therapeutics is based in Belgium and will leverage UCBs neurology expertise in modulating the synaptic vesicle protein SV2A. Thanks for submitting! Regulating synaptic transmission represents a promising approach to treating Alzheimer's Disease and other disorders with cognitive impairment. About UCB Ventures. Syndesi Therapeutics is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment seen in multiple CNS disorders, including Alzheimers Disease, schizophrenia and depresson. The pharmaceutical industry's most comprehensive news and information delivered every month. Four years after spinning out from Belgium's UCB, Syndesi Therapeutics and its SV2A modulator programme has been bought by AbbVie for $130 million upfront. UCB is listed on Euronext Brussels (symbol: UCB). In addition to being the major shareholder in the Novo Group companies, Novo Holdings provides seed and venture capital to development-stage companies, takes significant ownership positions in well-established companies within the life sciences and manages a broad portfolio of financial assets. Macrophage Therapeutics has developed a proprietary targeted steroid (MT-2000 class) designed to specifically treat the disease-causing cells quarterbacking the body's inflammatory response (Macrophages). document.getElementById('cloak45869').innerHTML = ''; Fountain Healthcare Partners (www.fh-partners.com) is a life science focused venture capital fund with 176 million ($200 million) under management. Tom Hudson, senior vice president, R&D, and chief scientific officer of AbbVie, said that his company plans to evaluate the Syndesi molecule in a range of brain disorders. AbbVie announced it has completed the acquisition of Syndesi Therapeutics SA, which will help to expand AbbVie's neuroscience portfolio. The companys drugs are small molecules that modulate synaptic transmission, which is the communication that happens between neurons in the brain. The objective of the fund is to invest in the development of start-ups, from validation of the technology to commercial maturity. The biotech notes that disruption of the synaptic connectivity is found in Alzheimers and other types of dementia. Important factors that could result in such differences include: changes in general economic, business and competitive conditions, the inability to obtain necessary regulatory approvals or to obtain them on acceptable terms, costs associated with research and development, changes in the prospects for products in the pipeline or under development by UCB, effects of future judicial decisions or governmental investigations, product liability claims, challenges to patent protection for products or product candidates, changes in laws or regulations, exchange rate fluctuations, changes or uncertainties in tax laws or the administration of such laws and hiring and retention of its employees. Cleary Gottlieb Steen & Hamilton LLP acted as legal counsel to AbbVie. Le ratio de marge brute ajuste tait de 84,7 % ; la marge d'exploitation du deuxime trimestre tait de . About Syndesi Therapeutics Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. Syndesi Therapeutics is a Pharmaceutical Company located in Belgium, Europe, and was founded in 2018. Syndesi Therapeutics SA, a clinical stage biotechnology company developing novel modulators of the synaptic vesicle protein SV2A for the treatment of cognitive impairment, provides an update on the clinical development of its lead molecule, SDI-118, and announces an extension of its series A financing. Synaptic dysfunction is believed to. COPENHAGEN, Denmark, March 1, 2022 /PRNewswire/ -- Novo Holdings, a leading international life sciences investor, today announces that its portfolio company Syndesi Therapeutics ('Syndesi'). "With AbbVie's acquisition of Syndesi, we aim to advance the research of a novel, first-in-class asset for the potential treatment of cognitive impairment associated with neuropsychiatric and neurodegenerative disorders.". This investment group formed Syndesi in 2017; the startup licensed SDI-118 from UCB in 2018. "Le dynamisme de notre activit, combin aux avances de notre pipeline, continue de soutenir les perspectives prometteuses d'AbbVie long terme." Sur une base GAAP, le ratio de marge brute du deuxime trimestre tait de 71,4 %. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. Other executives include John Kemp, Chief Scientific Officer; Torsten Madsen, Chief Medical Officer and 4 others. Founded in 1973, JJDC continues a legacy of customizing deals for data-driven companies across the continuum of healthcare, with the goal of turning great ideas into transformative new pharmaceutical, medical device and consumer healthcare products. SIRP-DIRECTED ANTIBODIES IN DEVELOPMENT Our novel monoclonal antibodies are designed to change the lives of patients with immunological diseases and cancer. Share. V-Bio Ventures was established in 2015 and works closely with Belgium-based VIB, one of the worlds premier life science institutes. North Chicago, Illinois-based AbbVie announced Tuesday that it paid $130 million up front to acquire Syndesi Therapeutics. Request Profile Update Download Data Home Profiles Pharmaceutical Company Europe Syndesi Therapeutics Syndesi Therapeutics Details Syndesi Therapeutics Contact Information Get News Stories Delivered to Your Inbox Your Email: Join Today They are also entitled to get further contingent payments of up to $870m on meeting specific pre-set milestones. Moreover, sales may be impacted by international and domestic trends toward managed care and health care cost containment and the reimbursement policies imposed by third-party payers as well as legislation affecting biopharmaceutical pricing and reimbursement. Novo Holdings and Fountain Healthcare Partners are the most recent investors. AbbVies Syndesi acquisition gives the pharma company an additional shot at neurodegeneration. Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic . READ MORE ABOUT US. Synaptic dysfunction, with the consequent disruption of connectivity bet ween brain regions, underlies cognitive impairment seen in multiple CNS . IMPROVING THE LIVES OF PATIENTS AND THEIR FAMILIES. You are at any time able to change your cookie preferences via the cookie settings on the website. About Syndesi Therapeutics Syndesi Therapeutics (www.syndesitherapeutics.com) has been established at the Centre d'Entreprises et d'Innovation (CEI) in Louvain-la-Neuve and will have a presence at the JLINX incubator facilities to access expertise at the Janssen campus in Beerse, Belgium. . With an upfront payment of $130 million, AbbVie gains Syndesi's portfolio of novel modulators of the synaptic vesicle protein 2A (SV2A), including its lead molecule SDI-118. The AbbVie/Calico alliance, started in 2014, has advanced three programs to clinical testing in neurodegeneration and cancer. This acquisition gives AbbVie access to Syndesi's portfolio of novel modulators of the synaptic vesicle protein 2A (SV2A), including its lead molecule SDI-118. Within the life science sector, specific areas of interest to Fountain include specialty pharma, medical devices, biotechnology and diagnostics. Sirona's current pipeline includes further cosmetic related products for cell preservation and repair, keloid therapy, scar therapy, anti-aging, anti-wrinkle, and . read more 14 Dec "There is a major unmet need for new therapies that can help improve cognitive function in patients suffering from difficult-to-treat neurologic diseases," saidTom Hudson, M.D., senior vice president, R&D, chief scientific officer, AbbVie. The mechanism is currently being evaluated for the potential treatment of cognitive impairment and other symptoms associated with a range of neuropsychiatric and neurodegenerative disorders, such as Alzheimer's disease and major depressive disorder. THE INNOVATIVE TEAM AT ELECTRA THERAPEUTICS Our team expands the possibilities of science to create transformative therapies for patients in need. Contact Email info@syndesitherapeutics.com Phone Number +32 10 280 238 Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). See the full leadership team at Craft. In June last year, AbbVie exercised an exclusive option for the acquisition of TeneoOne, a Teneobiosubsidiary. It also presents a list of recommendations for addressing these challenges. Discover our pipeline Founded in 2019, Augustine Therapeutics is a biotech company in Leuven, Belgium. Bone Therapeutics has a broad portfolio of innovative allogeneic cell therapy solutions across a range of indications. Syndesi has an exclusive, worldwide license from UCB to develop and commercialise a series of novel, pro-cognitive SV2A modulators. Syndesi's Series A financing was co-led by Novo Holdings together with Fountain Healthcare Partners, with participation from Johnson & Johnson Innovation JJDC, Inc., SRIW (Socit Rgionale d'Investissement de Wallonie), V-Bio Ventures and Vives Fund, along with UCB Ventures. UCB - Inspired by patients. Syndesi benefits both from UCBs research expertise and from an impressive syndicate of experienced investors and their respective networks., Cognitive impairment remains an area of significant unmet need for patients not only with Alzheimers Disease but also more broadly across a range of neurological disorders, and we are excited about the potential promise of this novel therapeutic approach, says Morten Graugaard Dssing, Principal at Novo Seeds. . Johnson & Johnson Innovation JJDC Inc. (JJDC) is the strategic venture capital arm of Johnson & Johnson and a long-term investment partner to global healthcare entrepreneurs.

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