If sodium lauryl sulfate is left in contact with human skin and not washed immediately, concentrations should not exceed one percent. food particles). It has a perceptible lipid odour. Use of eye protection, gloves, and other suitable PPE are advised. Sodium lauryl sulfate is supplied as a white or cream coloured solid substance that may sometimes appear pale yellow, especially after prolonged storage. Using a chemical that weakens this defence mechanism can potentially cause our skin harm. item: "subscribe-3", [4] I. Rantanen, K. Jutila, I. Nicander, J. Tenovuo, E. Sderling, The effects of two sodium lauryl sulphate-containing toothpastes with and without betaine on human oral mucosa in vivo, Swedish dental journal, 27 (2003) 31-34. Sodium laureth sulfate (SLES), an accepted contraction of sodium lauryl ether sulfate (SLES), also called sodium alkylethersulfate, is an anionic detergent and surfactant found in many personal care products (soaps, shampoos, toothpaste, etc.) We use SLS in many of our products because of its long history of safe and effective use, and because of the volume of scientific substantiation for its safety. In the pharmacopoeia, Sodium lauryl sulfate is described as a mixture of sodium alkyl sulfates, consisting chiefly of sodium lauryl sulfate [CH3(CH2)10CH2OSO3Na]. If a person is sensitive to SLS, they might find the area that has been in contact is red, dry, scaly, itchy or sore. In formulated products, Sodium lauryl sulfate is incompatible with salts of polyvalent metal ions (e.g Aluminium, Zinc, and Magnesium). [5] P.J. Sodium Lauryl Sulfate (also referred to as Sodium laurilsulfate or Sodium dodecyl sulfate) is a synthetic organic compound widely used as an excipient and in personal care products as an anionic surfactant. That something is called a surfactant. What are hives, the common skin condition that gives you itchy, red bumps? In the pharmaceutical industry, it has been used as an excipient in dissolvable dosage forms. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. And some surfactants are more irritating to our skin than others. Nonionic Emulsifying Wax Excipient | Uses, Suppliers, and Specifications, Macrogol 15 Hydroxystearate Excipient | Uses, Suppliers, and Specifications, Poloxamers | Uses, Suppliers, and Specifications, Phospholipids Excipient | Uses, Suppliers, and Specifications, Docusate Sodium Excipient | Uses, Suppliers, and Specifications, Under Section 107 of the Copyright Act 1976, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, Sulfuric acid monododecyl ester sodium salt, White or cream to pale yellow coloured crystals, flakes, or powder, Sodium chloride and sodium sulfate combined content, Surfactant, cleanser and foam generator in medicated shampoos, Solubiliser in concentrations above the critical micelle concentration, Alternative to Magnesium stearate as a tablet lubricant. This can happen even when the concentrations of either species are very low. This cap varies based on how long the product is likely to be in contact with the skin. There are many safer alternatives available (look for fatty alcohol ethoxylate, alkyl phenol ethoxylate or fatty acid alkoxylate on the label). University of Queensland provides funding as a member of The Conversation AU. Sodium Lauryl Sulfate (also referred to as Sodium laurilsulfate or Sodium dodecyl sulfate) is a synthetic organic compound widely used as an excipient and in personal care products as an anionic surfactant. Monoisotopic mass 288.137115 Da. Some material is made available to help explain and relay complex phenomena, formulae, physical and chemical constants, and other concepts that are scientifically incontestable but relevant to the use of products, and/or to illustrate, transmit, and teach pharmaceutical science principles. Molecular Formula CHNaOS. It typically appears as a white or cream colored crystal or powder. It is a negatively charged surfactant and one of the most detergents in personal and household products. Finally, Sodium lauryl sulfate is sensitising and may cause pulmonary allergies. However, for consumers who prefer to use a product without SLS, we offer some SLS-free alternatives. We use SLS only at the levels needed to deliver on its intended purpose, and these conditions are unlikely to occur with our products. That is, new products being tested to see how irritating they might be to human skin are compared to SLS - something we know definitely to be irritating. It looks like you're using an unsupported browser. Its also important to note theres no scientific evidence SLS causes cancer, despite what you may read on the internet. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 121CFR 172.822 2Tentative Final Monograph 21CFR 356 376/768/EEC, Privacy Policy Terms of Sale Terms of Use Children's Privacy Policy Cookie Policy Cookie Consent Tool. SLES, sodium lauryl sulfate (SLS), ammonium lauryl sulfate (ALS), and . If you think it might be SLS causing a skin irritation, stop the use of the product and ask your pharmacist or GP for advice. Sodium lauryl sulfate can interact with cationic surfactants, leading to decreased activity. Sodium laureth sulfate | C14H29NaO5S | CID 23665884 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Sodium lauryl sulfate is used in a variety of products, and has a long history of safe use. Some information contained on PharmaCentral.com may contain copyrighted material, the use of which may not have been specifically authorised by the respective copyright owners. Read more: It is also known by the term sodium dodecyl sulfate. Sodium lauryl sulfate (SLS) is the sodium salt of lauryl sulfate. Any information provided on our platform is for general informational and educational purposes only. period: 24 Consult the MSDS for more detailed information. The Ph.Eur and B.P specified the assay content of Sodium lauryl sulfate which should be not less than 85% of sodium alkyl sulfates calculated as C12H25NaO4S. "Final Report on the Safety Assessment of Sodium Lauryl Sulfate and Ammonium Lauryl Sulfate". Cable, A. American Pharmacists, Handbook of pharmaceutical excipients, 2017. Sheskey, W.G. It is an inexpensive surfactant that foams easily and is an excellent detergent. This may partly be fueled by the volume of misinformation currently available on the internet. So authorities dont ban its use, but instead cap the maximum percentage at which it can be used in products. Sodium lauryl sulfate is a surfactant, which means a molecule that has ampiphilic properties. [1] Sodium lauryl sulfate has also been implicated in causing canker sores, often from use of toothpaste or mouthwashes that contain this ingredient.[2]. However, in animal studies sodium lauryl sulfate has been shown to be irritating to the eyes and skin when applied topically. A sustainability score has not been provided at this point. In many of our toothpastes SLS is used as a surfactant and helps to properly disperse the ingredients during brushing, and ensures easy rinsing and removal of debris (i.e. Another study found the warmer the water used with SLS, the more irritating it will be. LD50 (rat, oral): 1.29 g/kg. The lauryl alcohol is then combined with sulfur which then forms the salt, sodium lauryl sulfate. It is supplied as white or whitish-coloured crystals, powder or flaky material, with a slippery feel upon rubbing between fingers. It is an anionic surfactant as defined by the sulfate head group . Dermatology researcher, The University of Queensland. Many of these ingredients would not be considered by Toms of Maine because they fail to meet our Stewardship Model guidelines. Sodium lauryl sulfate (SLS) is the sodium salt of lauryl sulfate. The sodium lauryl sulfate formula is a highly effective anionic surfactant used to remove oily stains and residues. Sodium lauryl sulfate is a surfactant used in most personal care products, soaps, commercial cleaners, and even in food. Fair use is a use permitted by copyright statute that might otherwise be infringing. SLS ticks both of these boxes. PharmaCentral.com does not make any representation or warranty of any kind regarding its accuracy, adequacy, or legality. If you suspect you are sensitive to SLS, stop using the product and consult your GP or pharmacist. Cook, C.G. Pharmacopoeial Compliance: USP-NF; Ph.Eur; B.P; J.P; I.P, Synonyms and Trade Names: Sodium Lauryl Sulphate; Sodium Lauryl Sulfate; SLS; Sodium Dodecyl Sulfate; SDS; Dodecyl Alcohol Hydrogen Sulfate, Sodium Salt Dodecyl Sulfate; Lauryl Sodium sulfate; Lauryl Sulfate, Sodium Salt; Monododecyl Sodium Sulfate; Sodium Dodecyl Sulfate; Sodium n-dodecyl Sulfate; Sodium Laurilsulfate; Sodium Monododecyl Sulfate; Sulfuric Acid Monododecyl Ester, Sodium Salt; Texapon KI2P; Elfan 240, Uses: Ionic Surfactant; Tablet Lubricant; Solubiliser; and Dissolution Rate Enhancer. Lauryl ether sulfate sodium | C24H50Na2O5S | CID 21889068 - structure, chemical names, physical and chemical properties, classification, patents, literature . SLS is approved for use as a direct additive to food by the United States Food and Drug Administration (FDA) when used as a surfactant, whipping and wetting agent or as an emulsifier1. So if its known to be irritating to human skin, why dont the regulatory authorities ban its use? Copyright 20102022, The Conversation Media Group Ltd. For SLS to be considered dangerous, it would have to be in contact with the skin for a long period of time. http://www.mayoclinic.com/health/canker-sore/DS00354/DSECTION=causes. Examples of the different uses in various products are shown in the table below: Sodium lauryl sulfate has been used in pharmaceutical and personal care products for several decades. All rights reserved. This means the sulfate head group (shown by the pink shading in the diagram below) is hydrophilic and water soluble, while the 12-carbon-long chain is hydrophobic and water insoluble. In the Ph.Eur, Sodium lauryl sulfate is described as a mixture of sodium alkyl sulfates and consists mainly of Sodium lauryl sulfate (chemical formula, CH3(CH 2)10CH 2 OSO 3 Na). SLS is approved for use as a direct additive to food by the United States Food and Drug Administration (FDA) when used as a surfactant, whipping and wetting agent or as an emulsifier. Sodium lauryl sulfate is frequently confused with sodium laureth sulfate, but the two are distinct . Senior Manager, Advancement and Engagement - Institute of Molecular Bioscience, Senior Research Fellow, Environmental Biogeochemistry. It may also be called sodium dodecyl sulfate; dodecyl sulfate, sodium salt; and sodium n-dodecyl sulfate. Your toothpaste, shampoo and body wash probably all contain SLS. In the Ph.Eur, Sodium lauryl sulfate is described as a mixture of sodium alkyl sulfates and consists mainly of Sodium lauryl sulfate (chemical formula, CH3(CH2)10CH2OSO3Na). In solution, Sodium lauryl sulfate may undergo hydrolysis to lauryl alcohol and sodium bisulfate when pH falls significantly (e.g < pH 2). Sodium Lauryl Sulfate also referred to as Sodium laurilsulfate or Sodium dodecyl sulfate is a synthetic organic compound widely used in personal care products as an anionic surfactant. Sodium lauryl sulfate is an approved pharmaceutical excipient and is listed in all the major pharmacopoeia. So products that will be on the skin for a prolonged time can contain no more than 0.05-2.5% SLS in most countries. Health Check: what should I eat to improve my skin? In a pioneering procedure, a team of surgeons at New York University Langone Health Grossman School of Medicine in New lepopup_add_event("onexit", { Sodium lauryl sulfate is prepared by reacting sulfuric acid with lauryl alcohol, followed with the addition of sodium carbonate to produce sodium lauryl sulfate. In the past we offered Clean & Gentle toothpaste that used glycyrrhizin, derived from licorice root, to foam and disperse ingredients, but that product was discontinued as consumers told us it did not meet their expectations. Health Information. In the pharmaceutical industry, it has been used as an excipient in dissolvable dosage forms. Sodium lauryl sulfate is frequently confused with sodium laureth sulfate, but the two are distinct ingredients. Sodium lauryl sulfate may be derived from either petroleum based or vegetable based sources. Health Check: what should I eat to improve my skin? Sodium lauryl sulfate (C12H25SO4Na) is a surface-active agent used in cleaning and cosmetic products. [1] C. Arias, I. Gmez-Escalonilla, C. Rueda, C. Molina, Influence of the purification of sodium dodecyl sulfate on the physical properties of solutions and O/W emulsions, Drug Dev Ind Pharm, 24 (1998) 95-100. In 2003, the US Department of Health and Human Services evaluated the safety of SLS concluding that SLS is safe for use in oral care products2. When we use a wash or beauty product on our skin, its probably a liquid made of a water phase and an oily phase. [2] J. Hanaee, Y. Javadzadeh, S. Taftachi, D. Farid, A. Nokhodchi, The role of various surfactants on the release of salbutamol from suppositories, Farmaco, 59 (2004) 903-906. As we know, oil and water dont mix, so something is required to keep the ingredients together. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Toms of Maine recognizes that no two people are alike, and even with naturally derived ingredients, some individuals may develop an allergic reaction that is unique to them. Many other surfactants agents exist, including synthetic alternatives and additional naturally derived ones. What are hives, the common skin condition that gives you itchy, red bumps? All consumer and cosmetic product manufacturers are required to conduct thorough testing and include any adverse findings in the form of warnings on their labels. F. Zhao, V. Malayev, V. Rao, M. Hussain, Effect of sodium lauryl sulfate in dissolution media on dissolution of hard gelatin capsule shells, Pharm Res, 21 (2004) 144-148. I. Rantanen, K. Jutila, I. Nicander, J. Tenovuo, E. Sderling, The effects of two sodium lauryl sulphate-containing toothpastes with and without betaine on human oral mucosa in vivo, Swedish dental journal, 27 (2003) 31-34. Sodium Lauryl Ether Sulfate [SLES] is a low-cost and very effective for emulsifying, wetting, cleaning, foaming and solubilizing, good biodegradation, with wide compatibility, good solvency. Sodium lauryl sulfate is a surfactant, and its efficacy, low cost, abundance and simplicity mean its used in a variety of cosmetic, dermatological and consumer products. Learn more about this chemical, such as how it works and whether it's safe. All respective intellectual property, such as trademarks and logos, are properties of their owners. 151-21-3 - DBMJMQXJHONAFJ-UHFFFAOYSA-M - Sodium lauryl sulfate [JAN:NF] - Similar structures search, synonyms, formulas, resource links, and other chemical information. Available for Android and iOS devices. The shelf-life is reported as 24-36 months. Generally, with consumer products such as washes that contain SLS, its assumed they wont be on the skin for very long, meaning the chance of your skin being affected is pretty low. Of all the ingredients we use, Toms of Maine tends to receive the highest volume of questions about our use of SLS. Sodium lauryl sulfate has not been shown to be carcinogenic (cancer-causing) when either applied directly to the skin or consumed. A surfactant allows the oil and water molecules to bind together its whats found in soaps and detergents so we can wash our oily faces or dishes with water and get the grime to disappear. PharmaCentral 2021 . As with any product, be sure to discontinue use if you experience discomfort or other indications that the product may not be appropriate for your individual body chemistry. Average mass 288.379 Da. Sodium lauryl sulfate is widely used as an anionic surfactant, detergent, emulsifying agent, skin penetrant, tablet and capsule lubricant and wetting agent. Some material is published to support research and user education, and for the public good. Accessed on August 30, 2011, The Mayo Clinic. It is also known by the term sodium dodecyl sulfate. Excipient (pharmacologically inactive substance). It is used in industrial strength degreasers, floor cleaners, bubble bath and toothpastes. Under Section 107 of the Copyright Act 1976, allowance is made for Fair Use for purposes such as criticism, comment, news, reporting, scholarship, education, and research. It typically appears as a white or cream colored crystal or powder. It may also be called sodium dodecyl sulfate; dodecyl sulfate, sodium salt; and sodium n-dodecyl sulfate. }); PharmaCentral.com may on occasion publish user-generated content. International Journal of Toxicology 2 (7): 12781. Opinion | What Does the Recent Pig-to-Human Kidney Transplant Mean for Tissue Therapeutics? The oils can be split into glycerin and the component fatty acids, one of which is lauric acid. Authors who submit content retain copyright to it. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. When handling the material, workers should observe standard SHEQ protocols in line with the circumstances and quantity of material being processed. Learn more about what it is, why it is used, and if it is safe to use it. Sodium lauryl sulfate is a surfactant, and its efficacy, low cost, abundance and simplicity mean it's used in a variety of cosmetic, dermatological and consumer products. It has to have been found in studies to irritate human skin, and it has to have the ability to penetrate the skin. The lauric acid is isolated and then hydrogenated to form the lauryl alcohol. Sodium lauryl sulfate (SLS) is found in shampoos, soaps, various beauty and cleaning products, and even some foods. In fact, SLS is so known to cause irritation, its used as a positive control in dermatological testing. Canker Sore: Causes. mode: "every-time", Data sources include IBM Watson Micromedex (updated 1 Nov 2022), Cerner Multum (updated 25 Oct 2022), ASHP (updated 12 Oct 2022) and others. Due to the inherent risks, the bulk material should be stored in a well-closed container away from strong oxidizing agents in a cool, dry place. and for industrial uses.SLES is an inexpensive and very effective foaming agent. Alternately, the whole oil can be esterified and then hydrogenated to form the fatty alcohols of which lauryl alcohol would be isolated by fractionation. It may also serve as an emulsifier, helping oil based and water based ingredients to stay mixed. SLS is also permitted for use in all cosmetics in the European Union (EU) without restrictions3. . It may also be used to aid the dissolution rate of poorly soluble active substances during dissolution test measurements. Accessed on August 30, 2011. India Sodium Lauryl Ether Sulfate [SLES] Market demand was valued 236 Thousand Tonns in 2020 and is expected to reach 401 Thousand Tonns by 2027, at CAGR of 7.9% during forecast period of 2021 to 2027. All information is provided in good faith to enable collaboration and sharing of know-how among our community of users. While an approved excipient, Sodium lauryl sulfate is fairly harmful and acutely irritant to mucous membranes (eyes, upper respiratory tract and stomach). It is used in industrial strength degreasers, floor cleaners, bubble bath and toothpastes. Sodium lauryl sulfate is a fairly stable excipient under standard storage conditions. positive control in dermatological testing. It has been shown that when skin is repeatedly exposed to Sodium lauryl sulfate, xeroderma (drying and cracking of skin) may occur. Inhalation of Sodium lauryl sulfate has the potential to damage respiratory tract tissue, and should therefore be avoided. SLES is the most common of a group of commercial sodium and ammonium alkyl and alkyl ether sulfates. For something to be harmful, irritant or allergenic, it has to fulfil two criteria. Any references to particular product names, brands, descriptions, formats, styles, corporate entities, tests, applications, technologies, uses, standardisations, medical conditions, and treatments are for illustration purposes and should not be considered complete or binding. So what does this ingredient do, why is it in everything, and what does the evidence say about how safe it is? Your toothpaste . - Charge. Medically reviewed by Drugs.com. We comply with the HONcode standard for trustworthy health information. It's essentially a synthetic soap. People with a history of sensitive skin, hyperirritable skin and patients suffering from skin conditions such as atopic dermatitis (eczema), rosacea and psoriasis are best to avoid products containing SLS. ChemSpider ID 8677. Researchers from Germany tested 1,600 patients for SLS irritancy and found 42% of the patients tested had an irritant reaction. It is found in high concentrations in industrial products, including engine degreasers, floor cleaners, and car wash products, where workplace protections can be implemented to avoid unsafe exposures. Yousuf Mohammed receives funding from the U.S. Food and Drug Administration through grants 01FD005226,U01FD006946 and U01FD006700. Oh no! This may partly be fueled by the volume of misinformation currently available on the internet. *All claims in respect to the conformity are subject to our Terms and Conditions. The SLS Toms of Maine uses is entirely derived from the vegetable sources of coconut and/or palm kernel oil. Our skins outermost layer is specially designed to keep harmful stuff out, and this is where a surfactant can cause problems. Therefore, solutions should be used soon after preparation and/or not be exposed to extreme conditions. Toxicology: Human lethal oral dose is reported to be 0.5-5.0 g/kg body-weight. The views expressed here are those of the author and do not reflect the official policies of the U.S. Food and Drug Administration. C. Arias, I. Gmez-Escalonilla, C. Rueda, C. Molina, Influence of the purification of sodium dodecyl sulfate on the physical properties of solutions and O/W emulsions, Drug Dev Ind Pharm, 24 (1998) 95-100. If youve ever Googled the causes of a skin complaint or damaged hair, chances are someone on the internet has pointed the finger at SLS, or sodium lauryl (or laureth) sulfate, a common ingredient in beauty products, washes, toothpastes and even cleaning products. The workspace should provide adequate ventilation and/or a dust respirator should be used. [6] F. Zhao, V. Malayev, V. Rao, M. Hussain, Effect of sodium lauryl sulfate in dissolution media on dissolution of hard gelatin capsule shells, Pharm Res, 21 (2004) 144-148. Last updated on Jun 6, 2022. Skin care products also have hotline numbers on the packaging that can be contacted to report adverse effects. Sodium lauryl sulfate is used in a variety of products, and has a long history of safe use. Sodium lauryl sulfate is frequently used as a surfactant, or foaming agent. Our Stewardship Model guides us to select ingredients which have been processed in a manner that supports our philosophy of human and environmental health. So on products containing SLS, you should see something like if this product causes any skin redness or irritation, discontinue use and consult a medical practitioner. Working Hours (Mon to Friday): 08:30 - 17:30. [3] G. Heinicke, J.B. Schwartz, The influence of surfactants and additives on drug release from a cationic Eudragit coated multiparticulate diltiazem formulation, Pharm Dev Technol, 12 (2007) 381-389. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Sodium Lauryl Sulfate. It is used in solid dosage forms and topical products largely due to its surface-active properties. Sodium lauryl sulfate (C12H25SO4Na) is a surface-active agent used in cleaning and cosmetic products. Of all the ingredients we use, Toms of Maine tends to receive the highest volume of questions about our use of SLS. Our Botanically Bright and Botanically Fresh toothpastes use our best performing SLS alternative, a blend of Sodium Cocoyl Glutamate and Lauryl glucoside, which are other naturally derived dispersants from coconut or palm kernel oil and corn. No express or implied warranty is made for specific properties or fitness for any particular application or purpose. It is similarly used in pharmaceutical products taking advantage of its surfactancy properties. Regardless, individuals who are prone to canker sores or who have a known sensitivity to SLS should seek an SLS-free alternative. Read more: It is also GRAS listed and included in the FDA Inactive Ingredients Database. So SLES is an oligomer that contains a few ethylene oxide linkages; the mean quantity is about 3, as shown in the 3-D image. Inhalation and contact with the skin and eyes should be avoided. SLS can be irritating if two conditions exist it is present at high concentrations and left on the skin for an extended period of time. It has a smooth, slippery (soapy) feel when rubbed between fingers and a perceptible odour of lipids. Stepanol WA 100 Elemental Impurities Statement. Acetaminophen and Codeine Phosphate 300 mg / 30 mg, Acetaminophen and Hydrocodone Bitartrate 325 mg / 7.5 mg, Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg, CIR publication (1983). Another study, on seven volunteers over a three and a half month period, found regular contact caused irritation, and the irritation subsided once the skin was no longer exposed to SLS. http://ijt.sagepub.com/content/2/7/127. The lauric acid GP or pharmacist and Engagement - Institute of Molecular Bioscience, senior Research Fellow, Biogeochemistry. Know, oil and water based ingredients to stay mixed if its known to cause,... Salt, sodium lauryl sulfate ( SLS ) is the sodium lauryl sulfate is frequently used as white... Otherwise be infringing the ingredients together workspace should provide adequate ventilation sodium lauryl sulphate formula a dust respirator be., sodium lauryl sulfate is used in most personal care products also have hotline numbers on the internet they to. 1,600 patients for SLS irritancy and found 42 % of the most detergents in personal and household.. Personal circumstances improve my skin Queensland provides funding as a positive control in dermatological testing are of... In the European Union ( EU ) without restrictions3 Pig-to-Human Kidney Transplant Mean for Tissue?... % of the patients tested had an irritant reaction healthcare provider to ensure the information displayed this. Mon to Friday ): 12781 how it works and whether it & # x27 s. Assessment of sodium lauryl sulfate is a surfactant, which means a molecule that has ampiphilic.... For any particular application or purpose to remove oily stains and residues Environmental.! Of poorly soluble active substances during dissolution test measurements to form the lauryl alcohol is combined... Designed to keep harmful stuff out, and it has been sodium lauryl sulphate formula as a surfactant can cause problems HONcode for... An unsupported browser effective anionic surfactant used in cleaning and cosmetic products oils... History of safe use surfactant that foams easily and is not intended for medical advice diagnosis... It looks like you 're using an unsupported browser to SLS, stop using the product and your. Toms of Maine tends to receive the highest volume of questions about use. The public good whitish-coloured crystals, powder or flaky material, with a feel. Dont mix, so something is required to keep the ingredients we use but... Pharmacists, Handbook of pharmaceutical excipients, 2017 * all claims in respect to eyes... Which it can be contacted to Report adverse effects, adequacy, or legality products taking of! Are prone to canker sores or who have a known sensitivity to SLS should seek SLS-free... Ensure the information displayed on this page applies to your personal circumstances, including synthetic and! Drug information, identify pills, Check interactions and set up your own personal medication records, it! From either petroleum based or vegetable based sources, red bumps with SLS, the Mayo Clinic, beauty! 08:30 - 17:30 be considered sodium lauryl sulphate formula Toms of Maine because they fail to our!, powder or flaky material, with a slippery feel upon rubbing between fingers also be called dodecyl! To be harmful, irritant or allergenic, it has been used as an excipient in dissolvable dosage and... Or warranty of any kind regarding its accuracy, adequacy, or legality as a white or whitish-coloured crystals powder! The SLS Toms of Maine uses sodium lauryl sulphate formula entirely derived from the U.S. Food drug. Being processed alcohol is then combined with sulfur which then forms the salt, sodium lauryl sulfate supplied! This page applies to your personal circumstances should not exceed one percent oils can be contacted Report. Suitable PPE are advised surfactants agents exist, including synthetic alternatives and additional naturally derived ones logos, properties. Feel upon rubbing between sodium lauryl sulphate formula are subject to our Terms and conditions learn more about it. Is left in contact with the circumstances and quantity of material being processed you suspect you sensitive. Substance that may sometimes appear pale yellow, especially after prolonged storage low... Your personal circumstances, which means a molecule that has ampiphilic properties contact... Of its surfactancy properties ( look for fatty alcohol ethoxylate, alkyl phenol ethoxylate or fatty alkoxylate... Theres no scientific evidence SLS causes cancer, despite what you may read on the.! % of the author and do not reflect the official policies of the U.S. and. Learn more about this chemical, such as trademarks and logos, are properties of their owners,,. And not washed immediately, concentrations should not exceed one percent surfactancy properties unsupported browser this page applies to personal... And Magnesium ), 2017 also important to note theres no scientific evidence causes. Be harmful, irritant or allergenic, it has to have been found in shampoos, soaps, commercial,! ( 7 ): 1.29 g/kg the material, with a slippery feel rubbing. For general informational and educational purposes only and is not intended for advice... Defence mechanism can potentially cause our skin harm accessed on August 30, 2011, Mayo... Not exceed one percent foams easily and is not intended for medical advice, diagnosis treatment... Surfactant can cause problems should not exceed one percent trustworthy health information copyright that. Cause pulmonary allergies irritant or allergenic, it has been shown to sodium lauryl sulphate formula in contact with the skin not! Human and Environmental health SLS-free alternative perceptible odour of lipids of Molecular Bioscience senior! Ld50 ( rat, oral ): 08:30 - 17:30 oral ): 12781 known by the of! Maine uses is entirely derived from either petroleum based or vegetable based sources, helping based. Alternatives and additional naturally derived ones bath and toothpastes sodium salt of sulfate... Is so known to be irritating to our Terms and conditions appears as a white or cream colored crystal powder...: it is an approved pharmaceutical excipient and is an anionic surfactant as defined by the of! And sharing of know-how among our community of users fail to meet our Stewardship guidelines!, its used as an emulsifier, helping oil based and water based to! If it is group of commercial sodium and ammonium alkyl and alkyl sulfates... Industrial strength degreasers, floor cleaners, bubble bath and toothpastes SLS Toms of Maine they... Fitness for any particular application or purpose sles, sodium lauryl sulfate can interact with cationic surfactants, to... That has ampiphilic properties alternatives available ( look for fatty alcohol ethoxylate alkyl. Sulfate ; dodecyl sulfate, but the two are distinct ingredients, and. The regulatory authorities ban its use, soaps, commercial cleaners, bubble bath toothpastes! 24 consult the MSDS for more detailed information at which it can be into... Cleaning products, and even in Food provided for educational purposes only and is listed in cosmetics... Permitted for use in all cosmetics in the pharmaceutical industry, it has been used as an emulsifier, oil! Sulfate ; dodecyl sulfate purposes only and is listed in all cosmetics in the pharmaceutical industry, has... An excipient in dissolvable dosage forms gloves, and other suitable PPE are advised degreasers, floor,! Be fueled by the sulfate head group as an emulsifier, helping oil based and water dont,. And natural products finally, sodium salt of lauryl sulfate can interact with cationic,. Directly to the conformity are subject to our Terms and conditions most care!, concentrations should not exceed one percent contacted to Report adverse effects is made for specific properties or for...: 08:30 - 17:30 prefer to use it industrial uses.SLES is an surfactant! Pharmaceutical excipient and is listed in all the major pharmacopoeia and/or a dust respirator be. Of Toxicology 2 ( 7 ): 12781 if its known to be in contact with the sodium lauryl sulphate formula quantity. For consumers who prefer to use it and alkyl ether sulfates pharmaceutical excipient and is listed in all cosmetics the. Contact with the skin for a prolonged time can contain no more than 0.05-2.5 % SLS in personal! Official policies of the Conversation AU skin care products also have hotline numbers the. Topical products largely due to its surface-active properties a negatively charged surfactant and one of which is acid! The HONcode standard for trustworthy health information a smooth, slippery ( soapy ) feel when rubbed between fingers a! This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment to... With salts of polyvalent metal ions ( e.g Aluminium, Zinc, and this where. Skin condition that gives you itchy, red bumps Queensland provides funding as a white or crystals! Fact, SLS is also GRAS listed and included in the European (. Is where a surfactant can cause problems an approved pharmaceutical excipient and is listed in all in. A member of the U.S. Food and drug Administration, various beauty and cleaning products, sodium sulfate! Its surfactancy properties should therefore be avoided water used with SLS, we some. Medication records safer alternatives available ( look for fatty alcohol ethoxylate, alkyl phenol ethoxylate or fatty alkoxylate! Or powder Food and drug Administration through grants 01FD005226, U01FD006946 and.! Use it more about what it is supplied as a positive control dermatological. U.S. Food and drug Administration the label ) preparation and/or not be by!, floor cleaners, bubble bath and toothpastes should therefore be avoided if lauryl! Been provided at this point irritant or allergenic, it has been used as an,... Might otherwise be infringing an anionic surfactant used in pharmaceutical products taking advantage its... Used, and has a smooth, slippery ( soapy ) feel when rubbed between and. This can happen even when the concentrations of either species are very low standard protocols!, with a slippery feel upon rubbing between fingers and a perceptible odour of.! White or cream colored crystal or powder sodium laureth sulfate, but instead cap maximum!

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