The relative amount of CaMKII in the cell lysates was adjusted to be the same level as WT. (A) Sleep parameters of mice expressing CaMKII WT or the T287 mutant shown in Fig 1G1I during light or dark periods. CaMKII WT or T287D were expressed under Camk2a promoter. Note that some of the mutated residues would not be the target of phosphorylation in vivo, the outcome of this screening does not directly confer the evidence of phosphorylation-dependent control. Anyone can earn credit-by-exam regardless of age or education level. Trigonometry C2 Exam Questions I Titudin venenatis ipsum ac feugiat. A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses.The neuron is the main component of nervous tissue in all animals except sponges and placozoa.Non-animals like plants and fungi do not have nerve cells.. Neurons are typically classified into three types based on their function. The kinase reaction was terminated by adding an equal volume of Solution B and incubating at 98 C for 30 min. Magenta lines and dashed blue lines indicate when the values for the T287D:T306D:T307D-expressing mice are significantly (p < 0.05) higher and lower, respectively. Most mathematical activity involves the discovery of Trig Ratios for multiples of 30, 45 & 60 degrees Statistics Paper 21 May/June 2019, 8MA0/21 pAAV, pUCmini-iCAP-PHPeB, and pHelper plasmid (Agilent, USA) were transfected into cells at 80% to 90% confluency using polyethyleneimine (Polysciences, USA). The samples were reduced, alkylated, and digested by proteases according to the PTS method [66] as described above except that 1 g of Lys-C and 1 g of trypsin were used for most of the samples, and 1 g of Lys-C and 1 g of Glu-C (Promega, USA) were used for the sample for quantifying S182 phosphorylation. CaMKII, calmodulin-dependent protein kinase II; WT, wild-type. Sum of moments about a point Sleep staging was performed in every 8-s epoch. double knockout; DMEM, Questions separated by topic from Further Pure 1 Maths A-level past papers. The product ion spectrum on the right shows that each product ion from the 5 different transitions in the 3 samples has a similar intensity distribution. Questions January 2009 Level up on all the skills in this unit and collect up to 3200 Mastery points! A series is defined as the sum of the terms of the sequence. Even so, it becomes necessary to model the genes in combination with their vehicle as well as in combination with the vehicle's environment. Questions on Triangles I : no significance. The stained brain sample was washed with PBS and then treated in CUBIC-R+ solution (45% (w/w) antipyrine, 30% (w/w) nicotinamide, 0.5% (v/v) N-butyldiethanolamine) for 3 days at 25 C for RI matching. Intersection of two straight lines The relative kinase activity measured by the level of phosphorylated substrate suggests that S26D, S182D, and T311D mutation leads to the loss of kinase activity similar to the kinase-dead K43R mutant (S12C Fig). light/dark; NREM, Second Derivatives Laboratory for Comparative Connections, RIKEN Center for Biosystems Dynamics Research, Chuo-ku, Kobe, Hyogo, Japan, Affiliation Completing the Square II Questions January 2011 Visualization, Affiliation Camk2b KO mice were generated using the triple-target CRISPR method described previously [16]. S1 Table summarizes the AAVs used in this study and their administration conditions. Mathematics Integrals Mice expressing the mCherry-fused AIP2 exhibited a decreased sleep duration and PWS along with a trend toward increased PSW compared with mice expressing the inactive mutant of AIP2 (RARA) (Fig 2E and 2F), demonstrating that the CaMKII/CaMKII kinase activity is critical for normal sleep induction and maintenance. Social construction of gender And the high prevalence of horizontal gene transfer in bacteria and archaea means that genomic combinations of these asexually reproducing groups are also transient in evolutionary time: "The traditional view, that prokaryotic evolution can be understood primarily in terms of clonal divergence and periodic selection, must be augmented to embrace gene exchange as a creative force. The proposed sleep maintenance effect is also supported by the increased sleep episode duration observed in T287D:T306D:T307D mice, while such effect is less evident in T287D mice (S10E Fig). Vectors: Shortest Distance between point & line Summing Finite Series I with limits, with geometric series, proof by induction The dashed lines trace the dynamics of T287 phosphorylation in the 0.5 mM Ca2+ condition. Error bars: SEM, *p < 0.05, **p < 0.01, ***p < 0.001. In this study, we demonstrated that the conditional induction or inhibition of CaMKII kinase activity could bidirectionally increase or decrease mammalian sleep duration. Leadership Validation, Solutions January 2013 Trigonometric Questions with Bearings "[21] They build vehicles to promote their mutual interests of jumping into the next generation of vehicles. Questions June 2007 Solutions January 2007, Questions May 2014 Integration: Mixed Examples I We used CaMKII deletion (del) mutant that lacks the C-terminal half involving the regulatory segment, linker region, and oligomerization domain [30]. Both DKO mice lines are deficient in behavioral circadian rhythmicity in constant dark (DD) [3538]. (A, B) Sleep/wake parameters (A) and sleep profiles (B) of mice expressing CaMKII T287-related mutants under the Camk2a promoter, averaged over 6 days. Its definitely not miraculous.2 Its experimental and often fails. We will look at: Worked solutions for some A-level maths past year examinations. AIP2, autocamtide inhibitory peptide 2; CaM, calmodulin; CaMKII, calmodulin-dependent protein kinase II; del, deletion; EEG, electroencephalogram; EMG, electromyogram; hSyn1, human synapsin-1; NREM, nonrapid eye movement; REM, rapid eye movement; SSS, snappy sleep stager; WT, wild-type; ZT, zeitgeber time. "A gene can have multiple phenotypic effects, each of which may be of positive, negative or neutral value. "[35] Richard Dawkins replied to this criticism in a later book, The Extended Phenotype, that Gould confused particulate genetics with particulate embryology, stating that genes do "blend", as far as their effects on developing phenotypes are concerned, but that they do not blend as they replicate and recombine down the generations. AAV, adeno-associated virus; CaMKII, calmodulin-dependent protein kinase Ii; DIO, double-floxed inverted open reading frame; EEG, electroencephalogram; EMG, electromyogram; NREM, nonrapid eye movement; REM, rapid eye movement; WT, wild-type; ZT, zeitgeber time. Validation, Infinite Series Calculator AIP2, autocamtide inhibitory peptide 2; CaMKII, calmodulin-dependent protein kinase II; del, deletion; hSyn1, human synapsin-1; https://doi.org/10.1371/journal.pbio.3001813.s006. For wireless recordings, anesthetized mice were implanted a telemetry transmitter (DSI, USA). Mutants marked in blue were selected for further analysis as sleep-canceling residues, related to Fig 6A. Discriminant of a Quadratic Equation II Disguised Quadratic Equations dendritic targeting element; EEG, Concepts that you will need to know for the A-level Maths: Algebra, Transformation of Graphs, Functions, Indices, Logarithms & Exponential, Polynomials, Geometry. The samples were separated by SDSpolyacrylamide gel electrophoresis and then transferred to a polyvinylidene difluoride (PVDF) membrane (Hybond-P PVDF membranes, Merck, Germany) by a wet-transfer apparatus (Vep-3, Thermo Fisher Scientific, USA). Composite Function Exam Questions Step 1: Enter the function in the first input field and apply the summation limits from and to in the respective fields. Binomial Expansion Formula After 10 days of recovery, the mice were placed in experimental cages with a connection of spring supported recording leads. Mathematics Mar 2020 Pure Maths 2 9709/22, Oct 2021 Pure Maths 3 9709/31 May 2022 Pure Maths 1 9709/12 Through such rescue experiments, it would be possible to approach the question not covered by the current study: Whether the sleep cancellation effect is related to the transition from sleep to awake phase in the natural sleepwake cycle or the cancellation of additional sleep needs upon unusual input such as sleep deprivation. PBS: PBS-administrated mice. Investigation, Factorising & Solving Quadratic Equations I After microinjection, the embryos were cultured for 1 h in KSOM medium (Merck, Germany, or ARK Resource, Japan) in a 5% CO2 incubator at 37 C. Mice brain samples shown in S5 Fig were also subjected to SRM analysis with mass spectrometry method for analyzing the phosphorylation of S26 (CaMKII) or S25 (CaMKII) residues. Integration by Parts Exam Questions I Sigma Notation Neuron Mark Schemes January 2009 Sewage contains wastewater Another common interpretation is that the integral of a rate function describes the accumulation of the quantity whose rate is given. Kinematics Vertical Motion II (A) The 29 serine and 40 threonine residues throughout CaMKII. This result also supports that these residues are the target of autophosphorylation at least in 293T cells, although we do not exclude the possibility that other kinases play a prominent role for the phosphorylation of these residues especially in the brain. Fractal We simulated 72-h EEG recording composed of consecutive 8-s epochs (dt = 8 s). The trapped peptides were subjected to dimethyl-labeling with formaldehyde (light label) as described above. Questions January 2012 We cannot quantify the S182 phosphorylation in the 293T condition because of our technical limitations in the detection of this peptide in crude samples. Magenta lines and dashed blue lines indicate when the values for the T287D-expressing mice are significantly (p < 0.05) higher and lower, respectively. Questions June 2010 The Remainder Theorem The gene-centered view of evolution is a model for the evolution of social characteristics such as selfishness and altruism.. Acquired characteristics. A-level Exam Paper 2 Q1 - Q4 Mark Scheme June 2012 Integration of Trigonometric Functions I Simultaneous Linear Equations Substitution (C) Sleep duration and correlation diagram of daily PWS and PSW of mice expressing CaMKII mutants with D or A substitutions of T306 and/or T307 residues. These lines of evidence suggest that loss of kinase activity elicited by S26 phosphorylation is involved in the physiological mechanisms that control the timing and/or the level of CaMKII activity. Pure Maths Paper 1 June 2018 Questions June 2013 Sigma It is also called sigma notation because the symbol used is the letter sigma of the Greek alphabet. Stationary Points I In both of SSS and EEG/EMG recordings, it is not clear whether there is a difference in the extent of the effect of T287D:T306D:T307D mutations on PSW between light and dark phases (S10F and S11A Figs). Factorising Cubics using the Factor Theorem II Project administration, Mark Schemes January 2010 May 2020 Pure Maths 2 9709/23 Genomic DNA of F0 mice tails was extracted with NucleoSpin Tissue kit (Takara Bio, Japan) according to the manufacturers protocol. This result again suggests that glutamatergic excitatory neurons are involved in the sleep promotion by the CaMKII T287D mutant. Khan Academy Statistics 1, 2, and 3 Error bars: SEM, *p < 0.05, **p < 0.01, ***p < 0.001, n.s., no significance. History of physics Area of a Triangle using Sine The novel cage environment promotes awakening by stimulating the mices exploratory behavior [28]. Viral particles were contained in a 40% solution, and this solution was ultrafiltered with an Amicon Ultra-15 device (100 kDa, Merck, Germany) to obtain the AAV stock solution for administration to mice. Mark Schemes January 2007 (D) Genomic locus obtained as Camk2b promoter sequence, mapped onto GRCm38/mm10 using UCSC genome Browser (http://genome.ucsc.edu/) [82]. AAV, adeno-associated virus; CaMKII, calmodulin-dependent protein kinase II; EEG, electroencephalogram; EMG, electromyogram; hSyn1, human synapsin-1; NREM, nonrapid eye movement; pA, polyA; REM, rapid eye movement; SSS, snappy sleep stager; UTR, untranslated region; WT, wild-type; ZT, zeitgeber time. Immunoreactivities of the blotted proteins were detected with Clarity Western ECL Substrate for Chemiluminescent Western Blot Detection (Bio-rad) and ChemiDoc XRS+ system (Bio-rad). Multiplying Polynomials In the SSS, sleep staging was performed every 8 s, which is the smallest unit called epoch. When we focus on 2 consecutive epochs, there are 4 combinations: keeping awake state (wake to wake), keeping sleep state (sleep to sleep), transition from wakefulness to sleep (wake to sleep), and transition from sleep to wakefulness (sleep to wake). Mark Scheme January 2007, A-level Exam Q1 - Q5 The Core units have been combined. Nevertheless, T287D:T306D:T307D has the sleep maintenance activity while the del mutant shows sleep induction activity (Fig 2B). Questions June 2009 We can approximate integrals using Riemann sums, and we define definite integrals using limits of Riemann sums. Systems are the subjects of study of systems theory and other systems sciences.. Systems have several common Solutions June 2013 Integration by Parts Exam Questions II Thus, the background kinase activity, if any, originated from endogenous 293T proteins would be the same among cell lysates. We determined the contribution of the ESCs in an obtained ES-mouse by its coat color following a previously reported protocol [74,75]. Methodology, Affiliations CaMKII, calmodulin-dependent protein kinase II; EEG, electroencephalogram; NREM, nonrapid eye movement; SSS, snappy sleep stager; WT, wild-type. https://doi.org/10.1371/journal.pbio.3001813.g004. Biology (B) Correlation diagram of daily PWS and PSW of mice expressing the CaMKII double-phopshomimetic mutants shown in Fig 5A, averaged over 6 days. Infinite Series Definition The procedure to use the summation calculator is as follows: The increased NREM and REM sleep duration as well as increased PWS were observed in both light and dark phases (S4A Fig). Pure Maths Mock Paper 2 2019 Equation of Circle Tutorial 4 The shaded areas represent SEM. Partial Fractions Tutorial III Range of Motion (C) Total CaMKII and T286-phosphorylated peptides from brains of sleep-deprived and control mice, analyzed by SRM quantitative mass spectrometry. Partial Fractions Exam Questions II PWS and PSW are independent of each other, and it can be deduced from the definition that PWS + PWW = 1 and PSW + PSS = 1. EEG/EMG recordings showed an increase in NREM and REM sleep duration (Fig 5D and 5E), a significant decrease in PSW, and no significant change in PWS (Fig 5F), which is consistent with the SSS analysis. (D) Sleep parameters during light or dark period of mice expressing CaMKII T287-related mutants shown in Fig 1F. LA is defined as the intersection of the distributions of delta power percentage in NREM and REM epochs. Questions January 2007 Cre-mediated recombination of AAV genomes results in Camk2b gene expression in the target cells. Parallel & Perpendicular Lines Infinite Series calculator is a free online tool that gives the summation value of the given function for the given limits. problem solver below to practice various math topics. Logs & Exponential Equations II Oct 2021 Prob & Stats 1 9709/52 To Gould, the fatal flaw was that "no matter how much power Dawkins wishes to assign to genes, there is one thing that he cannot give them direct visibility to natural selection. https://doi.org/10.1371/journal.pbio.3001813.s008. Further Pure Mathematics units available are Further Pure Mathematics 1, 2 & 3. If you're ready to pass your A-Level Biology exams, become a member now to get complete access to our entire library of revision materials. A system, surrounded and influenced by its environment, is described by its boundaries, structure and purpose and expressed in its functioning. Error bars: SEM, *p < 0.05, **p < 0.01, ***p < 0.001, n.s. Mark Schemes June 2013 Other sleep parameters were shown in Fig 1G1I. Modulus Graphs I Distinct phosphorylation states of mammalian CaMKII control Investigation, We also note that peptide phosphorylated with S26 can be found in vivo brain sample [4] (S13 Fig), although it is unable to distinguish CaMKII isoforms because of the identical sequence around the S26 phosphorylation site. Mouse CaMKII protein has 69 serine (S) and threonine (T) residues that can be the target of autophosphorylation (Fig 1A). On the other hand, changes in the PWS in T287D mice is more evident in the light phase, presumably because wake-associated signals of environmental dark environment antagonize the sleep-inducing effect of T287D mutant. Nathaniel Essex (Earth-616) | Marvel Database | Fandom Biology. Proving Trig Identities III Quadratic Log Equations Vestibulum ullamcorper Neque quam. Johann Carl Friedrich Gauss (/ a s /; German: Gau [kal fid as] (); Latin: Carolus Fridericus Gauss; 30 April 1777 23 February 1855) was a German mathematician and physicist who made significant contributions to many fields in mathematics and science. No, but I would to save two brothers or eight cousins. Carl Friedrich Gauss The role of such phosphatases in CaMKII-dependent sleep control needs to be investigated. Solutions May 2014 Oct 2020 Physics 1 9702/13, Mar 2021 Physics 2 9702/22 Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Roles Range of Motion Multiple comparison tests were performed between all individual groups. We have a collection of videos, solutions, activities, worksheets and past year Error bars: SEM, *p < 0.05, **p < 0.01, ***p < 0.001, n.s. Residues shown in red were selected for further analysis in an independent set of experiments. Vitamin D without a subscript refers to either D 2 or D 3, or both, and is known collectively as calciferol.. 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